Parallel MRI reconstruction using B-spline approximation Jan Petr petrj5@cmp.felk.cvut.cz Abstract: Parallel MRI is a technique that exploits the intrinsic spatial encoding of multiple receiver coils with distinct spatial sensitivities to speed up MRI data acquisition. The increase in data acquisition speed is achieved by sampling the k-space more sparsely in the phase encoding direction. Thus, not all image information is retrieved and the images are affected by aliasing. The missing k-space information is synthesized using the sensitivity information from the receiver coils. We present a new reconstruction method for parallel MRI that works in the image domain. Unlike other image-domain methods that estimates the reconstruction independently in each pixel using smoothed sensitivity maps, we represent the reconstruction transformation in B-spline basis and estimate the B-spline coefficients using the raw calibration images by minimizing the expected reconstruction error. This regularizes the estimation and makes the method more robust to noise in the reference images. We present the results achieved on simulated and in-vivo data and compare it with two widespread parallel MRI methods - GRAPPA and SENSE.